Advances in the study of neoantigen pulsed dendritic cell vaccines in tumor immunotherapy

VernacularTitle:新抗原脉冲树突状细胞疫苗在肿瘤免疫治疗中的作用
Author: Tong-Xin WANG ¹ ; Fan ZHANG ; Xin YAN ; Ya-Ting ZHANG ; Yu-Min LI
Author Information

1. 甘肃省消化系肿瘤重点实验室,甘肃兰州 730030;兰州大学第二医院肿瘤外科,甘肃兰州 730030
Keywords: neoantigen; dendritic cell vaccine; tumor; immunotherapy
From: Medical Journal of Chinese People's Liberation Army 2024;49(2):220-228
CountryChina
Language:Chinese
Abstract: Neoantigen pulsed dendritic cell vaccine(Neo-DCVac)is a new type of tumor immunotherapy.Neoantigen is strong immunologic and tumor-specific mutated peptides expressed in a tumor.Neo-DCVac is a therapeutic modality based on the uptake and processing of neoantigens by dendritic cells and their delivery and activation of T cells to trigger the body's immune response for anti-tumor effects.The development of individualized Neo-DCVac based on high-throughput sequencing is expected to be a new direction for precision immunotherapy of tumors.In this review,we discuss construction of individualized Neo-DCVac,clinical application of combination therapy in solid tumors,suitable population for vaccination and the current limitations of Neo-DCVac,aiming to provide a theoretical reference for research on tumor immunotherapy.