Omeprazole combined with different probiotics regulates intestinal microbiota to alleviate functional dyspepsia in children
10.16352/j.issn.1001-6325.2024.02.0219
- VernacularTitle:奥美拉唑联合不同益生菌调节肠道菌群减轻小儿功能性消化不良
- Author:
Yun HE
1
;
Li XIAO
;
Juan CAO
;
Zhigang LIU
;
Weiyao LUO
Author Information
1. 佛山市妇幼保健院 儿科,广东 佛山 528000;南方医科大学 第一临床医学院,广东 广州 510000
- Keywords:
omeprazole;
probiotics;
intestinal flora;
functional dyspepsia
- From:
Basic & Clinical Medicine
2024;44(2):219-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of omeprazole combined with different probiotics on regulating intestinal flora in reducing functional dyspepsia(FD)in children.Methods Two hundreds children with FD admitted to the Pediatric Department of Foshan Maternal and Child Health Hospital from January 2022 to February 2023 were se-lected as the study subjects.They were randomly divided into omeprazde(omep)group,groups of omeprazole+yeast(yeast group),+clostridium butyricum(clos group),and+bifidobacterium(bifi group)respectively.Results After treatment,serum level of IL-6,TNF-α,IL-1β,hs-CRP,VIP,SS,Enterobacter and Enterococcus in all groups significantly decreased as compared with the finding before treatment(P<0.05).Those targets in the three combined treatment groups were significantly lower compared to the ome group;After treatment,the serum MOT level,bifidobacteria,and lactobacilli in each group were significantly increased(P<0.05),and the results from three combined treatment groups demonstrated notably higher levels compared to the omep group(P<0.05);The scores of symptoms in all groups showed a significant alleviation after the treatment(P<0.05).Additionally,the three combined treatment groups exhibited significantly lower symptom scores than the group treated with omeprazole alone(P<0.05).There was no difference in the incidence of adverse reactions during treatment among the groups.Conclusions Omeprazole combined with different probiotics have achieved good results in the treatment of FD in children.
