Research progress of hypoxia inducible factor 1α in the mechanism of diabetic kidney disease
10.16352/j.issn.1001-6325.2024.01.0114
- VernacularTitle:低氧诱导因子-1α在糖尿病肾病中作用机制的研究进展
- Author:
Yahui ZHANG
1
;
Qiong BAI
Author Information
1. 北京大学第三医院 肾内科, 北京 100191
- Keywords:
hypoxia inducible factor 1α;
diabetic kidney disease;
pathogenesis
- From:
Basic & Clinical Medicine
2024;44(1):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1α(HIF-1α)is a nuclear transcription factor.Under high glucose and hypoxia conditions,the expression of HIF-1α is elevated,result in the increased expression of its downstream target genes VEGF,HO-1 and BNIP3,which affect angiogenesis,extra cellular matrix deposition,iron metabolism,and mito-phagy,participating in the occurrence and development of diabetic kidney disease(DKD).In addition,HIF-1α promotes inflammation and renal fibrosis by affecting the production of cytokines in DKD.
