Progress of researches on inducing hepatic stellate cell ferroptosis for treatment of liver fibrosis
10.16352/j.issn.1001-6325.2024.01.0108
- VernacularTitle:诱导肝星状细胞铁死亡治疗肝纤维化的研究进展
- Author:
Lijie SUN
1
;
Dandan HAO
Author Information
1. 赤峰学院附属医院 普外科, 内蒙古 赤峰 024005
- Keywords:
liver fibrosis;
hepatic stellate cell;
ferroptosis
- From:
Basic & Clinical Medicine
2024;44(1):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Emerging evidence suggests that ferroptosis,an iron-dependent form of regulated cell death,plays a criti-cal role in the genesis of liver fibrosis through inducing hepatic stellate cell(HSC)ferroptosis to inhibit liver fibrosis or inducing hepatic ferroptosis to potentiates liver fibrosis.Pharmacologically targeting at ferroptosis with its inducers can slow down the progression of liver fibrosis in vitro and in vivo model.This review suggests that pharmacological in-duction of HSC ferroptosis might be used as a potential novel targeted therapy for the treatment of liver fibrosis.
