Research progress on the role of lipoprotein-associated phospholipase A2 in acute coronary syndrome
10.16352/j.issn.1001-6325.2024.01.0103
- VernacularTitle:脂蛋白相关磷脂酶A2在急性冠状动脉综合征中作用的研究进展
- Author:
Jianhong GUO
1
;
Yaling WANG
;
Wenguang CUI
Author Information
1. 河北北方学院附属第一医院 心血管内科, 河北 张家口 075000
- Keywords:
lipoprotein-associated phospholipase A2;
acute coronary syndrome;
atherosclerosis
- From:
Basic & Clinical Medicine
2024;44(1):103-107
- CountryChina
- Language:Chinese
-
Abstract:
Lipoprotein-associated phospholipase A2(Lp-PLA2)is a protein composed of 441 amino acids,which can promote the aggregation of inflammatory cells to the inflammatory response site and the release of inflammatory factors.It can promote the synthesis of matrix metalloproteinases,increase the number of foam cells and extra cel-lular matrix in atherosclerotic plaque,attenuate plaque fiber cap and prone to rupture,thus promote the onset of acute coronary syndrome(ACS).Therefore,the determination and regulation of Lp-PLA2 levels in patients with ACS are clinically significant.
