Research progress on the mechanism of mesenchymal stem cells therapy for premature ovarian failure

VernacularTitle:间充质干细胞治疗卵巢早衰的机制研究进展
Author: Bayalige ¹ ; Xia HAN ; Sheng YUN
Author Information

1. 内蒙古医科大学附属医院干细胞研究中心,内蒙古呼和浩特 010050
Keywords: premature ovarian failure(POF); mesenchymal stem cells(MSCs)
From: Basic & Clinical Medicine 2023;43(12):1891-1895
CountryChina
Language:Chinese
Abstract: Premature ovarian failure(POF)is a gynecological endocrine disease caused by ovarian dysfunction.Mesenchymal stem cells(MSCs)can effectively treat premature ovarian failure,and play a role in repairing ovarian structure and improving ovarian function.The specific mechanism can be a direct differentiation into granulosa cells or inhibition of their apoptosis through the homing effect of MSCs or differentiate into primordial germ cells.Benefit of MSCs can also be attributed to ovarian angiogenesis promotion,immune regulation,reduce oxidative stress re-sponse and paracrine,all potentially promote recovery of ovarian function,and thus improve the fertility of women of childbearing age.