Study on the Synthesis,Structural Characterization and Activity of Fluorine-Containing Borneol Ester

VernacularTitle:含氟冰片酯的合成、结构表征及活性研究
Author: Chuan-Bing CHEN ¹ ; Hai-Tao WU
Author Information

1. 广州中医药大学,广东广州 510405
Keywords: borneol ester; fluorine-containing drug; molecular docking; chemical synthesis
From: Journal of Guangzhou University of Traditional Chinese Medicine 2024;41(4):1019-1022
CountryChina
Language:Chinese
Abstract: Objective Four fluorine-containing borneol ester were synthesized and analyzed for structure characterization and activity.Methods Four fluorine-containing borneol ester derivatives were synthesized by the reaction of fluorinated carboxylic acid and borneol by using p-toluenesulfonic acid as catalyst,and the structures of borneol esters were characterized by 1HNMR and 13CNMR.Molecular docking of the four fluorine-containing borneol ester with P-glycoprotein was carried out by Autodock Vina software.Results Four fluorine-containing borneol ester,bornyl 2-chloro-4-trifluoromethyl benzoate,bornyl 2-chloro-5-fluoro benzoate,bornyl 2-chloro-5-trifluoromethyl benzoate,bornyl 3-trifluoromethyl benzoate,were synthesized.The structures of the borneol ester were confirmed by 1HNMR and 13CNMR.4 fluorine-containing borneol ester had good binding ability with P-glycoprotein.Conclusion Four borneol ester compounds were synthesized,and the borneol ester enriched the types of borneol derivatives,which is of reference value for expanding the application range of borneol.