A Review of Research Status for the Anti-tumor Mechanism of Shanxian Granule
10.13359/j.cnki.gzxbtcm.2024.03.041
- VernacularTitle:山仙颗粒抑制肿瘤作用机制的研究概况
- Author:
Jing WEI
1
;
Han ZHOU
;
Xiao-Ya WANG
;
Yuan LI
;
Xiao-Ping YING
;
Yan FANG
Author Information
1. 陕西中医药大学基础医学院,陕西咸阳 712046
- Keywords:
Shanxian Granule;
liver cancer;
lung cancer;
sarcoma;
melanoma;
immune function;
cell proliferation;
apoptosis;
tumor angiogenesis;
review
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(3):809-814
- CountryChina
- Language:Chinese
-
Abstract:
In this article,the mechanism of Shanxian Granule in inhibiting liver cancer,lung cancer,sarcoma,melanoma and other tumors was reviewed,with a view to providing a theoretical basis for the clinical research of Shanxian Granules in the treatment of malignant tumors.Shanxian Granule are the pure Chinese medicine preparation for counteracting malignant tumor developed by the Oncology Research Team of Shaanxi University of Chinese Medicine on the basis of the theory of traditional Chinese medicine syndrome differentiation and treatment combined with decades of clinical experience as well as the achievements of modern pharmacological research.Shanxian Granule are mainly composed of Crataegi Fructus,Agrimoniae Herba,Panacis Quinquefolii Radix,Curcumae Rhizoma,Testudinis Carapax et Plastrum,Trionycis Carapax,Corydalis Rhizoma,and Polyporus,and have the actions of benefiting qi and nourishing yin,supporting healthy-qi and cultivating the essence,activating blood and removing stasis,and eliminating swelling and counteracting cancer.The compatibility of Shanxian Granule embodies the principle of supporting healthy-qi but avoiding maintaining pathogens,and eliminating pathogens but avoiding injuring healthy-qi.The granules can effectively inhibit the growth and metastasis of liver cancer,lung cancer,sarcoma,melanoma and other tumors both in vivo and in vitro,alleviate the clinical symptoms of tumor patients,and improve their prognosis.The anti-tumor mechanism of Shanxian Granules is related to the enhancement of body immune function,inhibition of tumor cell proliferation,enhancement of tumor cell apoptosis,inhibition of tumor cell invasion and metastasis as well as the tumor angiogenesis.
