Discussion on the relationship between symptoms and drugs in the treatment of fever with modified Zhuye Shigao Decoction based on data mining
10.3760/cma.j.cn115398-20220926-00379
- VernacularTitle:基于数据挖掘探讨竹叶石膏汤加减治疗发热的症药关系
- Author:
Haohui YIN
1
;
Chaofeng GUO
Author Information
1. 广西中医药大学2020级硕士研究生，南宁 530200
- Keywords:
Zhuye Shigao Decoction;
Fever;
Data mining;
Medication law
- From:
International Journal of Traditional Chinese Medicine
2023;45(12):1576-1581
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the symptoms and medication law of fever treated with modified Zhuye Shigao Decoction by means of data mining.Methods:Clinical medical records of modified Zhuye Shigao Decoction for the treatment of fever were retrieved from CNKI, VIP, Wanfang Data, CBM from the establishment of the databases to October 31, 2022. Excel 2019 was used to conduct statistics on symptoms and drug frequency. SPSS Modeler 18.0 and SPSS Statistics 25.0 were used to build complex networks and system clusters, and R 4.2.1 was used to analyze the association rules of the database. Results:A total of 163 medical records were included, involving 143 symptoms, mainly fever, anorexia, thirst, upset, sweating, etc; 40 tongue and pulse conditions, mainly including pulse number and red tongue; 163 kinds of Chinese materia medica were involved, including 9 main kinds of Chinese materia medica. The frequency and complex network of Chinese materia medica indicated that the main medicines for fever were the original prescriptions of Zhuye Shigao Decoction, and the commonly used doses were Folium Phyllostachydis Henonis 10 g, Gypsum Fibrosum 30 g, Ginseng Radix et Rhizoma or Codonopsis Radix 10 g, Ophiopogonis Radix 15 g, Pinelliae Rhizoma 10 g, Glycyrrhizae Radix et Rhizoma 6 g, and Oryzae Semen 15g; According to the clustering analysis of compatibility drugs, five core compatibility combinations were obtained. "Forsythiae Fructus→Lonicerae Japonicae Flos", "Adenophorae Radix→dry mouth" had strong correlation.Conclusion:The syndrome types of fever treated by Zhuye Shigao Decoction were unclear exogenous heat-qi and yin injury, phlegm and heat obstructing the lung, excessive heat in the interior-fluid deficiency and heat stagnation, stomach yin deficiency and fire hyperactivity, spleen and stomach weakness-edema due to yang deficiency; the cause of fever treated by Zhuye Shigao Decoction could originate from any of the three energizers, and the disease location was mainly in the stomach.
