Summary of molecular characteristics of iodine refractory differentiated thyroid carcinoma
10.3760/cma.j.cn115396-20230612-00172
- VernacularTitle:碘难治性分化型甲状腺癌分子特征概述
- Author:
Peng ZHANG
1
;
Yaohua WU
Author Information
1. 哈尔滨医科大学附属第一医院甲状腺外科，哈尔滨 150001
- Keywords:
Thyroid neoplasms;
Radio-iodinated;
Mutations
- From:
International Journal of Surgery
2023;50(9):643-648
- CountryChina
- Language:Chinese
-
Abstract:
The clinical manifestation of iodine-refractory differentiated thyroid cancer (RAIR-DTC)is resistance to iodine therapy, which can not achieve the therapeutic effect and affect the prognosis of patients. Iodine-refractory thyroid cancer is mainly due to the decrease or disappearance of the expression of sodium-iodine isotransporters, the expression of some thyroid specific genes and the change of signaling pathway caused by some gene mutations. In this paper, the molecular characteristics of RAIR-DTC will be introduced and expounded, hoping to enhance understanding of RAIR-DTC, and provide help for targeted drug therapy of it.
