Progress in application of engineered microorganisms in different diseases
10.3760/cma.j.cn121382-20231112-00108
- VernacularTitle:工程微生物在不同疾病治疗中的应用进展
- Author:
Ting CHEN
1
;
Wen LI
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Microorganisms;
Surface modification;
Genetic engineering;
Anti-inflammatory;
Anti-tumor
- From:
International Journal of Biomedical Engineering
2024;47(1):45-52
- CountryChina
- Language:Chinese
-
Abstract:
The human body contains a large microbial community composed of eukaryotes, archaea, bacteria, and phages. Bacteria are the most prominent members of this community, numbering in the same order of magnitude as human cells. Many commensal or pathogenic bacteria interact with their hosts through biochemical signals. Based on these bacterial properties, commensal and attenuated pathogens have been designed to deliver therapeutic molecules to target specific diseases. The engineered bacteria or bacteria-derived particles and their encapsulation, secretion, and expression of surface therapeutic molecules developed in the past five years were introduced. Their applications in anti-inflammatory, anti-tumor, thrombosis treatment, and imaging were reviewed, and the clinical translational potential of microbial drug delivery systems was discussed.
