Research progress on the role of neutrophils in progression and treatment of cancer
10.3760/cma.j.cn121382-20230821-00503
- VernacularTitle:中性粒细胞在癌症进展与治疗中作用的研究进展
- Author:
Weijia ZHANG
1
;
Linhua ZHANG
;
Dunwan ZHU
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Neutrophils;
Tumor-promoting effect;
Antitumor effect;
Chimeric antigen receptor
- From:
International Journal of Biomedical Engineering
2023;46(5):390-396
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophils are the most abundant population of white blood cells in the human circulation. They play a key role in the protection of the host against microbial infections as well as taking a critical part in inflammatory processes. Recently, several studies showed that neutrophils play an active role in the immune response during cancer development. Neutrophils and various immune cells constitute a significant part of the tumor immune microenvironment. Research has found that different subpopulations of neutrophils may promote or limit tumor growth, indicating that people should be more concerned about the potential of neutrophils. In this paper, the various functions of neutrophils in the progression and treatment of cancer and the possibility of using these functions as a new model of immunotherapy were reviewed.
