Pathogenesis of brain arteriovenous malformations
10.3760/cma.j.issn.1673-4165.2023.10.010
- VernacularTitle:脑动静脉畸形的发病机制
- Author:
Ren LI
1
;
Xiaogang WANG
;
Zi’ao LI
;
Geng GUO
Author Information
1. 山西医科大学第一医院神经外科，太原 030001
- Keywords:
Intracranial arteriovenous malformations;
Signal transduction;
Neovascularization, pathologic;
Inflammation;
Polymorphism, single nucleotide;
DNA methylati
- From:
International Journal of Cerebrovascular Diseases
2023;31(10):779-784
- CountryChina
- Language:Chinese
-
Abstract:
Brain arteriovenous malformations (bAVMs) are a complex congenital cerebrovascular disease. The lack of common capillaries results in blood flowing directly from the arteries to the veins, forming abnormal vascular malformations between the arteries and veins. BAVMs are usually found due to "epilepsy, intracranial hemorrhage, and focal neurological dysfunction", with a low incidence rate but a high mortality and disability rate. However, the specific pathogenesis of bAVMs is not fully understood. This article reviews the signaling pathways, pathophysiological mechanisms, and non-coding RNAs related to the pathogenesis of bAVMs, with the aim of providing new diagnostic and therapeutic strategies for bAVMs.
