The predictive value of serum IL-34 and suPAR for poor prognosis in children with asthma
10.3969/j.issn.1673-4130.2024.06.018
- VernacularTitle:血清IL-34、suPAR水平对哮喘患儿预后不良的预测价值
- Author:
Bo ZHOU
1
;
Wenchun LIU
Author Information
1. 恩施土家族苗族自治州中心医院儿童神经呼吸康复科,湖北恩施 445000
- Keywords:
asthma;
interleukin-34;
soluble urokinase-type plasminogen activator receptor;
progno-sis;
children
- From:
International Journal of Laboratory Medicine
2024;45(6):733-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum interleukin(IL)-34 and soluble uroki-nase-type plasminogen activator receptor(suPAR)for poor prognosis in children with asthma.Methods A total of 184 children with asthma admitted to the hospital from January 2020 to December 2021 were enrolled in the study as the asthma group,and 184 healthy children who underwent physical examination in the hospital during the same period were enrolled as the healthy group.Enzyme-linked immunosorbent assay(ELISA)was used to measure the serum levels of IL-34 and suPAR in the two groups.The children in the asthma group were followed up for 1 year,and the prognosis was evaluated using the Asthma Control Test(ACT)score ta-ble.Logistic regression was used to analyze the influencing factors of poor prognosis in children with asthma.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum IL-34 and suPAR levels for the prognosis of children with asthma.Results The asthma group had significantly higher serum levels of IL-34 and suPAR than the healthy group(P＜0.05).The incidence of poor prognosis was 22.65％(40/181).Compared with the good prognosis group,the poor prognosis group had significantly high-er proportion of children with preterm birth,passive smoking,a family history of asthma,a history of respira-tory infection,pet rearing,severe disease and serum levels of IL-34 and suPAR(P＜0.05),and a significantly lower proportion of children with breast feeding(P＜0.05).The multivariate Logistic regression analysis showed that preterm birth,family history of asthma,severe disease,and high levels of IL-34 and suPAR were risk factors for poor prognosis in children with asthma(P＜0.05),while breastfeeding was a protective factor(P＜0.05).The area under the ROC curve(AUC)of the combination of serum IL-34 and suPAR for predic-ting poor prognosis in children with asthma was 0.896(95％CI:0.842-0.936),which was greater than the AUC of IL-34 alone(Z=2.636,P=0.008)and the AUC of suPAR alone(Z=2.430,P=0.015).Conclusion Children with asthma have elevated serum levels of IL-34 and suPAR,both of which are risk fac-tors for poor prognosis in children with asthma.Both of them have a good predictive value for the prognosis of children with asthma,and the combination of the two has higher predictive efficiency.
