Relationship between the expression of IDO1 and KYNU in oral squamous cell carcinoma tissues and clinicopathologic features and prognosis
10.3969/j.issn.1673-4130.2024.06.007
- VernacularTitle:口腔鳞状细胞癌组织中IDO1、KYNU表达情况与临床病理特征及预后的关系
- Author:
Makexi HAILIDA
1
;
Fang YANG
;
Musha AIKEREMU
Author Information
1. 新疆医科大学附属肿瘤医院/新疆肿瘤医院门诊部,新疆乌鲁木齐 830011
- Keywords:
oral squamous cell carcinoma;
indoleamine 2,3-dioxygenase 1;
kynurenidase;
prognosis.
- From:
International Journal of Laboratory Medicine
2024;45(6):671-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of indoleamine 2,3-dioxygenase 1(IDO1)and kynure-ninase(KYNU)in oral squamous cell carcinoma(OSCC)and their relationship with pathological features and prognosis.Methods A total of 98 OSCC patients admitted to the hospital from January 2018 to June 2020 were enrolled in the study.OSCC tissue samples and corresponding adjacent tissue samples were collected.Im-munohistochemical method was used to detect the expression of IDO1 and KYNU in tissues.The relationship between IDO1 and KYNU expression and the clinicopathological characteristics of OSCC patients was ana-lyzed.Multivariate Cox regression analysis was used to analyze the factors affecting the prognosis of OSCC pa-tients.Results The positive expression rates of IDO1 and KYNU in OSCC tissues were higher than those in adjacent tissues(P＜0.05).The positive expression rates of IDO1 and KYNU in patients with poor differenti-ation,depth of invasion(DOI)＞5 mm,lymph node metastasis,and clinical stage Ⅲ-Ⅳ were higher than those in patients with medium or high differentiation,DOI＜5 mm,no lymph node metastasis,and clinical stage Ⅰ-Ⅱ,respectively(P＜0.05).The 3-year overall survival rates of OSCC patients with medium or high differentiation,DOI＜5 mm,no lymph node metastasis,clinical stage Ⅰ-Ⅱ,negative expression of IDO1,and negative expression of KYNU were higher than those of OSCC patients with low differentiation,DOI＞5 mm,lymph node metastasis,clinical stage Ⅲ-Ⅳ,positive expression of IDO1,and positive expression of KYNU,respectively(P＜0.05).Multivariate Cox regression analysis showed that DOI＞5 mm(HR=3.225,95％CI:1.496-6.954),positive expression of IDO1(HR=3.714,95％CI:1.941-7.105),positive expression of KYNU(HR=4.150,95％CI:1.887-9.124)were the influencing factors of the prognosis of OSCC patients(P＜0.05).Conclusion IDO1 and KYNU are highly expressed in cancer tissues of OSCC patients,which are closely related to the DOI,clinical stage,and differentiation degree of OSCC.IDO1 and KYNU are hopeful to be used as markers to assist in evaluating the prognosis of patients.
