The value of HPV DNA and HPV E6/E7 mRNA detection in screening for cervical lesions
10.3969/j.issn.1673-4130.2024.04.016
- VernacularTitle:HPV DNA和HPV E6/E7 mRNA检测在宫颈病变筛查中的价值
- Author:
Hantao SONG
1
;
Xiaojuan LIU
;
Fang LIU
;
Li CHANG
;
Jie TENG
Author Information
1. 四川大学华西第二医院检验科,四川成都 610041
- Keywords:
cervical lesions;
human papillomavirus;
cervical cancer
- From:
International Journal of Laboratory Medicine
2024;45(4):467-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of human papillomavirus(HPV)DNA and HPV E6/E7 mRNA detection in screening for cervical lesions.Methods A total of 619 patients who were screened for cer-vical lesions in West China Second University Hospital from September 2021 to August 2022 were selected as the study objects.The value of HPV DNA and HPV E6/E7 mRNA detection in cervical lesion screening was evaluated based on their pathological results.Results The positive rate of HPV DNA detection was 64.78％(401/619)and that of HPV E6/E7 mRNA detection was 60.74％(376/619)in 619 patients.Cervical lesion screening was mainly conducted in sexually active people aged 30-＜40 years and 40-＜50 years.The posi-tive rates of HPV DNA and HPV E6/E7 mRNA increased with the increase of cervical lesion grade.The sen-sitivity,positive predictive value and negative predictive value of the two methods were higher than those of HPV DNA or HPV E6/E7 mRNA detection.Conclusion The combined detection of the two methods can be used for screening cervical lesions at various pathological stages,which can provide greater guidance value in clinical diagnosis and treatment.
