The predictive value of serum MMP-9 and sTREM-1 in postoperative urinary tract infection in patients with ureteral calculi
10.3969/j.issn.1673-4130.2024.03.001
- VernacularTitle:血清MMP-9、sTREM-1对输尿管结石患者术后泌尿系统感染的预测价值
- Author:
Shan CANG
1
;
Fan ZHANG
;
Jia TAO
Author Information
1. 南京大学医学院附属鼓楼医院麻醉手术科,江苏南京 210000
- Keywords:
ureteral calculus;
matrix metalloproteinase-9;
soluble triggering receptor expressed on myeloid cells-1;
urinary tract infection
- From:
International Journal of Laboratory Medicine
2024;45(3):257-260,265
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum matrix metalloproteinase-9(MMP-9)and soluble triggering receptor expressed on myeloid cells-1(sTREM-1)in postoperative urinary tract infec-tion(UTI)in patients with ureteral calculi.Methods Among the ureteral calculi patients admitted to the De-partment of Urology in a hospital from October 2021 to October 2022,68 patients with postoperative UTI(UTI group)and 68 patients without UTI(non-UTI group)were selected as the study objects.Serum MMP-9 and sTREM-1 levels were detected by enzyme-linked immunosorbent assay(ELISA).Spearman method was used to analyze the correlation between serum MMP-9 and sTREM-1 levels and clinical data in UTI group,and the predictive value of serum MMP-9 and sTREM-1 levels in postoperative UTI in ureteral calculi patients was analyzed by receiver operating characteristic curve.The influencing factors of postoperative UTI in ureter-al calculi patients were analyzed by multivariate Logistic regression.Results Compared with non-UTI group,serum MMP-9 and sTREM-1 levels in UTI group were significantly increased,with statistical significance(P＜0.05).Correlation analysis showed that serum MMP-9 and sTREM-1 levels were positively correlated in UTI group(r=0.585,P＜0.001).The combined prediction of the area under the curve(AUC)for postopera-tive UTI in ureteral calculi patients was 0.961(95％CI:0.934-0.988).The sensitivity and specificity were 73.36％and 85.68％,respectively.The AUC predicted by MMP-9 and sTREM-1 was higher than that predic-ted by MMP-9 and STREM-1 alone(Z=25.420,P＜0.001;Z=21.531,P＜0.001).The levels of MMP-9 and sTREM-1 were the influencing factors of postoperative UTI in ureteral calculi patients(P＜0.05).Conclusion The serum levels of MMP-9 and sTREM-1 in postoperative UTI in ureteral calculi patients are increased,and the detec-tion of both levels has important predictive value for the occurrence of postoperative UTI in ureteral calculi patients.
