Detection of serum allergen-specific IgE antibody and analysis of epidemiological characteristics in 19 744 patients with type Ⅰ allergic diseases
10.3969/j.issn.1673-4130.2023.24.001
- VernacularTitle:19744例Ⅰ型过敏反应性疾病患者血清过敏原特异性IgE抗体检测及流行病学特征分析
- Author:
Xiaoyi SONG
1
;
Jiajia WANG
Author Information
1. 四川省医学科学院·四川省人民医院临床医学检验中心,四川成都 610072;电子科技大学医学院,四川成都 611731
- Keywords:
allergen;
type Ⅰ allergic disease;
specific immunoglobulin E;
positive rate
- From:
International Journal of Laboratory Medicine
2023;44(24):2945-2949
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the detection results and distribution characteristics of serum allergen-specific immunoglobulin(Ig)E in patients with type Ⅰ allergic diseases(hereinafter referred as allergic disea-ses)in Chengdu area,and to provide epidemiological data and diagnostic basis for the prevention and treat-ment of allergic diseases.Methods A total of 19 744 patients diagnosed with allergen-specific IgE antibody screening in Sichuan Academy of Medical Sciences·Sichuan Provincial People's Hospital from September 2018 to December 2022 were included in this study.The serum level of allergen-specific IgE antibody was de-tected by enzyme-linked immunosorbent rapid test strip technology.According to different age,gender,season and disease groups,the positive results of specific allergens were counted,and the distribution characteristics and rules of specific allergens were analyzed.Results Among the 19 744 patients with allergic diseases,8 406 were positive for allergen-specific IgE,and the positive rate was 42.57%.The main inhaled allergens were house dust mites(15.17%),house dust(10.86%)and cat dander(4.04%).Milk(2.26%),beef(1.68%)and egg white(0.86%)were the main food allergens.The positive rate of inhaled allergens was higher than that of food allergens(P<0.05).The positive rate of male was higher than that of female(P<0.05).The positive rate of allergens in patients aged 10-<18 years was the highest,and the main allergens were house dust mites,house dust and cat dander.The positive rate of allergens was the highest in autumn,followed by spring and winter,and the lowest in summer.The main allergens were house dust mites,house dust and cat dander.The positive rates of allergens in different types of allergic diseases were as follows:allergic rhinitis>allergic asthma>eczema>others>allergic purpura>urticaria.There were significant differences in all aller-gens except cod,crab,mango and peanut among different diseases(P<0.05).Conclusion The characteristics of patients with allergic disease in Chengdu area are as follows:inhaled allergens are the main allergens;males have a higher allerger positive rate;the majority of patients were 10-<18 years old;patients are prone to dis-ease in autumn;allergic rhinitis was the most common.This can provide a reference for the prevention and treatment of allergic diseases in this area.
