Progress on immune dysfunction in autism spectrum disorder
10.3760/cma.j.issn.1673-4408.2024.01.001
- VernacularTitle:孤独症谱系障碍的免疫功能紊乱研究进展
- Author:
Zhuotang ZHONG
1
;
Jianzhao ZHANG
;
Jian YANG
Author Information
1. 北京大学首都儿科研究所教学医院 100020
- Keywords:
Autism spectrum disorder;
Immune dysfunction
- From:
International Journal of Pediatrics
2024;51(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Autism spectrum disorder（ASD）is a serious neurodevelopmental disorder，with deficits in social and language communication，rigid behaviors，limited interests and activities. At present，research on the pathogenesis of ASD involving immunity has been making progress worldwide. In terms of cytokines（such as IL-1β，IL-8，IL-17，etc.）and ASD animal models，it has been found that the onset of ASD is associated with nervous system immune dysfunction，which may lead to synaptic function impairment. The purpose of this review is to describe the recent research on ASD and immune dysfunction to provide ideas for exploring the etiology，pathogenesis and potential therapeutic measures of ASD.
