Advances in the mechanism of NK cells in autoimmune diseases
10.3760/cma.j.issn.1673-4408.2023.11.014
- VernacularTitle:NK细胞在自身免疫性疾病中的作用机制研究进展
- Author:
Jingyi LU
1
;
Yanliang JIN
Author Information
1. 上海交通大学医学院上海儿童医学中心风湿免疫科 200127
- Keywords:
Natural killer cell;
Henoch-Sch?nlein purpura;
Systemic lupus erythematosus;
Rheumatoid arthritis
- From:
International Journal of Pediatrics
2023;50(11):777-781
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer(NK) cells are large granular lymphocytes differentiated from lymphoid progenitor cells, which play an important role in antiviral and anti-tumor by exerting cytotoxic function and producing cytokines.The alteration or imbalance of function of NK cells is closely related to the occurrence of autoimmune diseases.However, the role of NK cells in autoimmune diseases is rarely reported.In addition, as a bridge between innate and adaptive immunity, the role of NK cells in inflammation and immune regulation is also worth further investigation.This paper reviews the available studies on NK cells in rheumatoid arthritis, Henoch-Sch?nlein purpura, and systemic lupus erythematosus, in order to deepen the understanding and enhance the exploration of the relationship between NK cells, T and B lymphocytes, and the role of NK cells in the pathogenesis of autoimmune diseases.
