Advances in the RNA N6-methyladenine modification in regulating pubertal sexual development
10.3760/cma.j.issn.1673-4408.2023.11.008
- VernacularTitle:氮6-甲基腺苷RNA甲基化修饰调控青春期性发育研究进展
- Author:
Shaolian ZANG
1
;
Xiaoqin YIN
;
Pin LI
Author Information
1. 上海交通大学医学院附属儿童医院 上海市儿童医院内分泌科 200062
- Keywords:
Methylation modification;
Pubertal sexual development;
Epigenetics
- From:
International Journal of Pediatrics
2023;50(11):750-753
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenine(m 6A)has been identified as the most abundant, common and conserved internal RNA modification.RNA m 6A can couple different levels of gene regulation and may play an important role in epigenetic regulation(such as RNA splicing, translation, stabilization, and ectopic). Studies have shown that RNA m 6A methylation is an important factor in pubertal sexual development.The abundance of RNA m 6A methylation changed with the progression of pubertal development.The abnormalities of RNA m 6A methylation can lead to dysfunction of hypothalamic gonadotropin-releasing hormone(GnRH)neuronal networks.Those genes affected by RNA m 6A methylation may be critical targets in regulating puberty initiation.The review summarizes the research progress between RNA m 6A methylation and pubertal sexual development to provide the evidence to discover new therapeutic targets and improve the prognosis of the disease.
