Advances in biomarkers related to multi-omics of idiopathic short stature
10.3760/cma.j.issn.1673-4408.2023.11.007
- VernacularTitle:特发性矮小症多组学生物标志物的研究进展
- Author:
Xin FENG
1
;
Chunlin WANG
Author Information
1. 浙江大学医学院附属第一医院儿科，杭州 310003
- Keywords:
Child;
Idiopathic short stature;
Biomarker;
Multi-omics;
Pathogenesis;
Early diagnosis
- From:
International Journal of Pediatrics
2023;50(11):746-749
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic short stature(ISS)is a group of short stature with unclear etiology and pathogenesis, of which the cause is heterogeneous and complex, primarily due to a combination of genetic and environmental factors.ISS is generally exclusionary diagnosis due to the lack of specific symptoms, signs and biomarkers.Recently, with the development of various high-throughput detection technologies, the study of transcriptomics, proteomics, metabolomics, and microbiomics related to ISS has gradually become a hot topic, providing new ideas for elucidating the etiology, making an early diagnosis, and guiding treatment of ISS.In this paper, advances in the pathogenesis and early diagnosis of ISS by biomarkers associated with multi-omics are reviewed.
