Research progress of gut microbiome in the treatment of psoriasis

VernacularTitle:肠道菌群在银屑病治疗中的研究进展
Author: Zhuyuan WEN ¹ ; Ping WANG ; Aijun CHEN
Author Information

1. 重庆医科大学附属第一医院皮肤科,重庆 400016
Keywords: psoriasis; gut microbiome; probiotics; biologics
From: Chongqing Medicine 2024;53(1):1-4,10
CountryChina
Language:Chinese
Abstract: Psoriasis is a chronic,recurrent,systemic inflammatory skin disease that is immune-media-ted.The balance and communication between the intestinal microbiota and its metabolites and the host play an important role in maintaining the body's normal functions,such as immune homeostasis and vitamin synthe-sis.Recent studies have found that compared with the healthy individuals,the psoriasis patients have experi-enced significant changes in the abundance and diversity of intestinal microbiota,including an imbalance in in-testinal microbiota,reduced production of short-chain fatty acids(SCFAs),and abnormal Firmicutes/Bacte-roidetes(F/B)ratio.The gut microbiota also changed after systematic medication treatment,biologic agents treatment and small molecule chemotherapy,indicating that the gut microbiota could be a potential biomarker for assessing treatment efficacy.The relationship between psoriasis and gut microbiota is not fully under-stood,and further research is needed.