Advances in the application of optical genomic mapping technology in precise diagnosis and treatment of hematologic malignancies
10.3760/cma.j.cn115356-20231113-00073-1
- VernacularTitle:光学基因组图谱在血液肿瘤精准诊疗中的应用进展
- Author:
Tong WANG
1
;
Yang ZHANG
;
Ming LIU
;
Hongxing LIU
Author Information
1. 河北燕达陆道培医院检验医学科，廊坊 065201
- Keywords:
Hematologic neoplasms;
Cytogenetics;
Optical genome mapping;
Genomic structural variationi
- From:
Journal of Leukemia & Lymphoma
2024;33(1):25-28
- CountryChina
- Language:Chinese
-
Abstract:
Optical genome mapping (OGM) is a novel non-sequencing genetic analysis technology that enables high-precision analysis of structural variations across the entire genome. It possesses unique technical advantages, and its procedural simplicity makes it easy to implement. In recent years, the application efficacy of OGM technology in the analysis of genomic structural variations in hematologic malignancies has been widely validated and recognized. Increasing evidence indicates that the application of OGM technology can help improve the genetic diagnosis, prognostic stratification and treatment guidance of hematologic malignancies. This article draws upon pertinent reports from the 65th American Society of Hematology Annual Meeting to provide an overview of the progress in applying OGM technology for the precise diagnosis and treatment of hematologic malignancies.
