HPV-independent gastric type adenocarcinoma of the uterine cervix presenting as ovarian masses: A case report and review of literature
https://doi.org/10.21141/PJP.2021.06
- Author:
Joseph Antoine Chatto
1
;
Annette Salillas
2
Author Information
1. Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines
2. Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines;Matias H. Aznar Memorial College of Medicine, Cebu City, Philippines
- Publication Type:Case Reports
- Keywords:
Cervical adenocarcinoma;
Gastric-type cervical adenocarcinoma;
HPV-independent cervical adenocarcinoma
- From:
Philippine Journal of Pathology
2021;6(1):50-55
- CountryPhilippines
- Language:English
-
Abstract:
Adenocarcinoma, HPV-independent, gastric type of the uterine cervix comprises only 10-15% of all cervical adenocarcinomas. A rare case of which, with metastasis to the uterine corpus and bilateral ovaries, is described. A 43-year-old female (G0P0) presented with menorrhagia and right flank pain radiating to the hypogastrium. Physical examination revealed an immovable, tender mass at the right lower quadrant with a nodular, firm cervix. Transabdominal ultrasound revealed multiseptated ovarian masses. The right and left ovaries were sent for frozen section and was diagnosed as Mucinous Cystadenoma and Mature Cystic Teratoma, respectively. Hysterectomy revealed a detached and fragmented cervix with irregular, abnormally shaped glands lined by a single layer of columnar cells with bland, basally located nuclei and clear cytoplasm associated with desmoplasia, findings which were also seen in the endomyometrium and ovaries. These tumor cells were CK7 positive and negative for ER, PR, CK20 and CDX2. The patient died six months after surgery. The presence of benign appearing glands is a diagnostic challenge. Despite the appearance, they may be malignant and should be investigated rigorously.
- Full text:34 PJP.pdf
