Application status and prospect of organ from hepatitis C donor in solid organ transplantation
10.3969/j.issn.1674-7445.2023207
- VernacularTitle:丙型病毒性肝炎供者器官在实体器官移植中的应用现状与展望
- Author:
Zhiwen QIN
1
;
Wu ZHANG
2
Author Information
1. Zhejiang Chinese Medical University, Hangzhou 310000, China;.
2. .
- Publication Type:ExpertForum
- Keywords:
Hepatitis C;
Hepatitis C virus;
Marginal donor;
Solid organ transplantation;
Direct-acting antiviral agent;
Sustained virological response;
Viremia;
Donor shortage
- From:
Organ Transplantation
2024;15(3):390-397
- CountryChina
- Language:Chinese
-
Abstract:
As a marginal organ donor, organs from hepatitis C donors have been applied in solid organ transplantation. While effectively alleviating the shortage of organs, it also faces certain challenges, such as the spread of hepatitis C virus (HCV). With the emergence and application of direct-acting antiviral agent, the cure of hepatitis C has gradually become a reality, laying the foundation for hepatitis C patients to become organ transplant donors. At present, with adjuvant treatment using antiviral drugs, certain efficacy has been achieved in solid organ transplantation from hepatitis C donors. In this article, research progress in kidney, heart, lung and liver transplantation from hepatitis C donors, the application of hepatitis C donors in solid organ transplantation and the safety and effectiveness of antiviral drugs were reviewed, and the feasibility of hepatitis C donors in solid organ transplantation was evaluated, aiming to provide reference for expanding the donor pool of organ transplantation and shortening the waiting time for organ transplantation in patients with end-stage diseases.
