Mechanism and application in tissue engineering of the active ingredient of Drynariae Rhizoma promoting bone defect repair
- VernacularTitle:骨碎补活性成分促进骨缺损后骨重建的机制及其组织工程学应用
- Author:
Zhijun DENG
1
;
Wenlong YANG
2
;
Zhijun YANG
1
;
Bin ZHAO
1
;
Dian LI
1
;
Fengyun YANG
2
Author Information
1. Graduate School，Jiangxi University of Chinese Medicine，Nanchang 330004，China
2. Dept. of Orthopedics，the Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330006，China
- Publication Type:Journal Article
- Keywords:
Drynariae Rhizoma;
active ingredient;
total flavonoids;
bone defect;
bone tissue engineering
- From:
China Pharmacy
2024;35(8):1023-1028
- CountryChina
- Language:Chinese
-
Abstract:
Bone defect has always been a major clinical challenge because of its great difficulty and long period of treatment. Drynariae Rhizoma is a commonly used medicine in osteology and traumatology of traditional Chinese medicine， and its active ingredients（mainly flavonoids） facilitate osteoblast differentiation of bone marrow mesenchymal stem cells， osteoclast proliferation， vascular-osteogenic coupling， and inhibit osteoclast activity to promote bone mineralization， and repair and reconstruction of bone defect. As a good substitute for bone regeneration drugs， the active constituents of Drynariae Rhizoma can be loaded on scaffold materials of tissue engineering， which greatly improves the bioavailability of the drug. Meanwhile， the sustained-release microspheres also solve some problems such as sudden drug release from the scaffolds， and the composite scaffolds with active ingredient of Drynariae Rhizoma prepared by them have good ossification activity and osteoinduction， with precise bone repair effects， which meet the diverse performance requirements of bone grafts and have a promising clinical application prospect.
