A new xanthone from the Polygala tenuifolia Willd. of northern Shaanxi
10.16438/j.0513-4870.2023-0919
- VernacularTitle:陕北细叶远志中的一个新𠮿酮
- Author:
Yun-peng JIA
1
;
Lu LIU
1
;
Xiao-jun YANG
1
;
Chao WANG
1
;
Huo-bing REN
2
Author Information
1. College of Chemistry and Chemical Engineering, Yan'an University, Yan′an 716000, China
2. Shaanxi Yuankang Traditional Chinese Medicine Industry Development Co., Ltd., Suide 718000, China
- Publication Type:Research Article
- Keywords:
italic>Polygala tenuifolia Willd.;
chemical composition;
xanthone;
acetylcholinesterase inhibitory activity
- From:
Acta Pharmaceutica Sinica
2024;59(3):667-672
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were isolated and purified from ethanol extracts of dried roots bark of Polygala tenuifolia Willd. by various chromatography techniques such as silica gel and Sephadex LH-20. Their structures were identified by analysis of physicochemical properties and spectral data, and determined as β-sitosterol (1), tenuifolin (2), 6-methoxy coumarin (3), 7-phenyl-1-hydroxy-2,3,6-trimethoxyxanthone (4), 1,8-dihydroxy-3,4,7-trimethoxyanthone (5), mangiferin (6), quercetin-3-O-β-D-glucoside (7), rutin (8), syringaldehyde (9), salicylicacid (10). Among them, compounds 3, 4 and 5 were isolated from the genus of Ploygala for the first time and compound 4 was a new xanthone. The acetylcholinesterase inhibitory activities of compounds 3, 4 and 5 were evaluated by Ellman colorimetric method, compounds 3 and 5 exhibited moderate inhibitory activity, compound 4 exhibited weak inhibitory activity.
