A new suberin from roots of Ephedra sinica Stapf
- VernacularTitle:草麻黄根中一个新软木脂类化合物
- Author:
Bo-wen ZHANG
1
;
Meng LI
1
;
Xiao-lan WANG
1
;
Ying YANG
1
;
Shi-qi ZHOU
1
;
Si-qi TAO
1
;
Meng YANG
1
;
Deng-hui ZHU
1
;
Ya-tong XU
1
;
Wei-sheng FENG
1
;
Xiao-ke ZHENG
1
Author Information
- Publication Type:Research Article
- Keywords:
root of
Ephedra sinica Stapf; chemical constituent; suberin; (Z )-docosanylferulate; antidepressant activity - From: Acta Pharmaceutica Sinica 2024;59(3):661-666
- CountryChina
- Language:Chinese
-
Abstract:
Six compounds were isolated from the roots of
Ephedra sinica Stapf using various chromatographic techniques such as silica gel column chromatography, thin layer chromatography and semi-preparative HPLC. Their chemical structures were identified by analysis of physicochemical properties and spectral data, and determined as (Z )-docosanylferulate (1 ), (E )-docosanylferulate (2 ),bis (2-ethylheptyl) phythalate (3 ), 2,2′-oxybis (1,4-di-tert -butylbenzene) (4 ), diisobutyl phthalate (5 ),bis (2-ethylhexyl) phthalate (6 ). Among them, compound1 is a new compound, compounds2 -4 were first isolated fromEphedra. A corticosterone-induced PC-12 cell injury model was used for compound activity screening. The results showed that compounds1 and5 significantly improved corticosterone-induced PC-12 cell injury and significantly increased 5-HT7 receptor protein expression in the cells, indicating potential antidepressant activity.
