Role of the Hedgehog signaling pathway in hepatocellular carcinoma and its tumor microenvironment

VernacularTitle:Hedgehog信号通路在肝细胞癌中的作用及其与肿瘤微环境的关系
Author: Xiaohua ZHANG ¹ ; Ying FENG ¹ ; Xianbo WANG ¹
Author Information

1. Department of Integrated Traditional Chinese and Western Medicine， Beijing Ditan Hospital， Capital Medical University， Beijing 100102， China
Publication Type:Review
Keywords: Carcinoma， Hepatocellular; Tumor Microenvironment; Hedgehog Signaling Pathway
From: Journal of Clinical Hepatology 2024;40(4):822-827
CountryChina
Language:Chinese
Abstract: The Hedgehog （Hh） signaling pathway plays an important role in the development and progression of hepatocellular carcinoma and its tumor microenvironment， and abnormal activation of Hh signal can accelerate the growth of tumor. The crosstalk between the Hh signaling pathway and TME is closely associated with tumor growth and the formation of inhibitory tumor microenvironment. Evidence shows that inhibition of Hh signal plays an important role in inhibiting the growth of hepatocellular carcinoma. This article reviews the current research status of the role， mechanism， and potential therapeutic significance of abnormal activation of Hh signal in hepatocellular carcinoma and its tumor microenvironment， so as to provide new ideas for the treatment of hepatocellular carcinoma.