Mechanism of amino acid metabolism in nonalcoholic fatty liver disease
- VernacularTitle:氨基酸代谢在非酒精性脂肪性肝病中的作用机制
- Author:
Hui ZHANG
1
;
Ming TAN
1
;
Shengtao CHENG
1
;
Juan CHEN
1
Author Information
- Publication Type:Review
- Keywords: Non-alcoholic Fatty Liver Disease; Amino acids; Metabolomics
- From: Journal of Clinical Hepatology 2024;40(4):810-815
- CountryChina
- Language:Chinese
- Abstract: Nonalcoholic fatty liver disease （NAFLD） is one of the most prevalent chronic liver diseases in the world， affecting about one quarter of the global population， and it is estimated that NAFLD will become the main indication for liver transplantation by 2030. NAFLD can lead to significant abnormalities in the levels of a variety of amino acids including branched-chain amino acids， thereby promoting the development and progression of NAFLD. These results suggest that in addition to glucose and lipid metabolism， amino acid metabolism also plays an important role in the progression of NAFLD. In order to systematically understand the role and mechanism of amino acid metabolism in NAFLD， this article reviews the research advances in amino acid metabolism in NAFLD. This article aims to explore the role and mechanism of amino acid metabolism in the progression of NAFLD， so as to provide ideas and a theoretical basis for clinical prevention and treatment.
