Effect and Mechanism of N-acetylcysteine in Ischemic Stroke
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2024.0203
- VernacularTitle:N-乙酰半胱氨酸在缺血性脑卒中的作用及机制
- Author:
Chen YANG
1
;
Wenhui WAN
1
Author Information
1. Department of Geriatrics， Jinling Hospital， Affiliated Hospital of Medical School of Nanjing University， Nanjing 210002， China
- Publication Type:Review
- Keywords:
N-acetylcysteine;
ischemic stroke;
oxidative stress;
inflammation;
thrombolysis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(2):190-195
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke （CIS） refers to ischemic necrosis or softening of localized brain tissue caused by cerebral blood circulation disorders， ischemia and hypoxia. The incidence of CIS is the highest among cerebrovascular diseases. Reduced supply of oxygen and nutrients leads to severe loss of neurons and deficits in brain function in stroke patients. Developing treatments for ischemic stroke remains an important challenge in clinical medicine. The antioxidant N-acetylcysteine （NAC） is a precursor of glutathione， and evidence from animal models of ischemic stroke and some clinical studies suggest that NAC can effectively protect the brain from ischemic damage. In this paper， the mechanism of NAC in CIS is described from various aspects， such as anti-oxidation， inhibition of inflammation， protection of cerebral nerve and mitochondrial function， stabilization of arterial plaque and thrombolytic function， aiming to explore the relationship between NAC and CIS in depth from the basic level， and to provide a theoretical basis for the further application of NAC in the prevention and treatment of patients with ischemic stroke.
