Relationship between self-reported occupational noise exposure and expression levels of plasma inflammatory cytokines in adult asthmatic patients
10.3969/j.issn.1006-2483.2024.02.022
- VernacularTitle:自报职业性噪声暴露与成人哮喘患者血浆中炎性细胞因子表达水平的关联性分析
- Author:
Yang WANG
1
;
Lianfeng LI
1
;
Yuqin SHI
1
;
Ling ZHANG
1
;
Ming WANG
2
;
Weihong CHEN
2
;
Ting ZHOU
1
Author Information
1. School of Public Health , Wuhan University of Science and Technology , Wuhan , Hubei 430065 , China;Hubei Province Key Laboratory of Occupational Hazard Identification and Control , Wuhan University of Science and Technology , Wuhan , Hubei 430065 , China
2. School of Public Health , Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430030 , China
- Publication Type:Journal Article
- Keywords:
Self-reported occupational noise exposure;
Adult asthma;
Soluble CD14;
Complement factor D;
Eotaxin 11
- From:
Journal of Public Health and Preventive Medicine
2024;35(2):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the relationship between self-reported occupational noise exposure and levels of plasma inflammatory cytokines in asthmatic patients. Methods A total of 910 adult asthmatic patients were selected as the study subjects, and their occupational noise exposure history and other related information were collected. The peripheral blood samples were collected from the patients, and the expression levels of plasma soluble CD14 (sCD14), complement factor D (CFD), Eotaxin-11 (CCL11), and IL-9 were determined. The relationship between self-reported occupational noise exposure and the expression levels of the four inflammatory cytokines in patients’ plasma were analyzed using multiple linear regression models. The interactions between confounding factors and self-reported occupational noise exposure were further analyzed by interaction analysis. Results The plasma CCL11, sCD14 and CFD expressions in asthmatic patients with self-reported occupational noise exposure were significantly higher than those in patients without the exposure (P<0.05). After adjusting for confounding factors, compared with patients reporting no occupational noise exposure, the plasma CFD expression was increased by 0.17 (95% CI: 0.02, 0.31) natural logarithm units in patients with self-reported occupational noise exposure. During remission, the levels of plasma CCL11 and sCD14 in asthmatic patients with self-reported occupational noise exposure were increased by 0.27 (95% CI: 0.05, 0.49) and 0.22 (95% CI: 0.02, 0.41) natural logarithm units, respectively, when compared with patients without the exposure. Interaction analysis showed that self-reported occupational noise exposure had significant multiplicative interaction with smoking or pet ownership on plasma CCL11 or CFD expressions in asthmatic patients (all P<0.05). Conclusion Self-reported occupational noise exposure is significantly associated with increased expression levels of plasma CFD, CCL11, and sCD14 in adult asthmatic patients.
