Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma.
10.11637/kjpa.2014.27.2.79
- Author:
Guang Hai YAN
1
;
Yun Ho CHOI
Author Information
1. Department of Anatomy and Histology and Embryology, Yanbian University School of Basic Medical Sciences, 977 Gongyuan Road, YanJi City 133002, Jilin, China.
- Publication Type:Original Article
- Keywords:
Lentinus edodes;
Asthma;
Allergic inflammation;
Th2 cytokine;
NF-kappaB
- MeSH:
Agaricales;
Animals;
Asthma*;
Bronchoalveolar Lavage Fluid;
Cytokines;
Eosinophils;
Ethanol;
Inflammation*;
Inhalation;
Interleukin-5;
Lung;
Mice;
NF-kappa B;
Ovalbumin;
Ovum;
Protein Kinases;
Shiitake Mushrooms*
- From:Korean Journal of Physical Anthropology
2014;27(2):79-90
- CountryRepublic of Korea
- Language:English
-
Abstract:
Medicinal mushrooms have been shown to have profound health promoting benefits. Among them, Lentinus edodes is well-known to have anti-tumor, anti-inflammatory, and immunomodulatory effects. The aim of the present study is to evaluate whether Lentinus edodes ethanol extract (LE) inhibit airway inflammatory response in a murine asthma model induced by exposure to ovalbumin (OVA). The pretreatment of LE substantially attenuated airway hyperresponsiveness and eosinophilic inflammation in OVA-challenged mice. In addition, the increased levels of Th2 cytokines (IL-4, IL-5, and IL-13), eotaxin, and adhesion molecules in bronchoalveolar lavage fluids at 48 h after OVA inhalation was significantly reduced by the administration of LE. Furthermore, LE suppressed OVA-induced activation of nuclear factor-kappa B and p38 mitogen-activated protein kinase in lung tissues. Taken together, it is proposed that LE may serve as an effective therapeutic agent for allergic airway disease.
