Role and Mechanism of Intestinal NDRG2 Mediating Visceral Hypersensitivity Following Exposure to PTSD
10.3969/j.issn.1008-7125.2021.03.003
- Author:
Jing WANG
1
;
Yanjun WANG
1
;
Weiwei ZENG
1
;
Dongfeng CHEN
1
;
Min YANG
1
;
You WANG
2
;
Yangmei CHEN
2
;
Tianwei DENG
3
;
Huaping LIANG
4
;
Jianmin WANG
5
;
Jian ZHANG
6
Author Information
1. Department of Gastroenterology, Daping Hospital, Army Medical University
2. Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University
3. Department of Gastroenterology, Three Gorges Hospital of Chongqing University
4. Department of Wound Infection and Drug, Daping Hospital, Army Medical University
5. Department of Weapon Injury Bioeffect Assessment, Daping Hospital, Army Medical University
6. Department of Biochemistry and Molecular Biology, Basic Medical College, Air Force Medical University
- Publication Type:Journal Article
- Keywords:
Ceftriaxone;
Genes, NDRG2;
Stress Disorder, Post-Traumatic;
Visceral Hypersensitivity;
Visceromotor Reflex
- From:
Chinese Journal of Gastroenterology
2021;26(3):139-144
- CountryChina
- Language:Chinese
-
Abstract:
Background: Visceral hypersensitivity is considered as a key pathophysiological mechanism involved in functional gastrointestinal disorders (FGIDs). Visceral nociception and hyperalgesia is existed extensively following exposure to post-traumatic stress disorder (PTSD), however, its molecular mechanism in intestinal tract is unclear. Aims: To explore the potential role of N-Myc downstream-regulated gene 2 (NDRG2) in intestinal tract for mediating visceral hypersensitivity following exposure to PTSD. Methods: PTSD model was established by single prolonged stress (SPS). SD rats were divided into normal control group, CTX group, PTSD group and PTSD+CTX group. Mice were divided into normal control group, PTSD group, NDRG2
