Effect of Fluoxetine on Metabolic Diversity of Intestinal Microbiota in Rats With Depression
10.3969/j.issn.1008-7125.2021.06.005
- Author:
Yu LI
1
;
Xiaojun CAI
1
;
Yanpeng XIE
1
;
Tao WANG
1
;
Qin WANG
1
;
Yuanyuan WU
1
;
Zhenhua LU
2
Author Information
1. Department of Endocrinology, Heilongjiang Provincial Hospital of Traditional Chinese Medicine
2. Department of Gastroenterology, Heilongjiang Provincial Hospital of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Biolog-ECO;
Depression;
Fluoxetine;
Intestinal Microbiota;
Metabolic Diversity
- From:
Chinese Journal of Gastroenterology
2021;26(6):342-347
- CountryChina
- Language:Chinese
-
Abstract:
Background: Studies have shown that intestinal microbiota is closely related to the occurrence and development of depression, however, the regulatory mechanism of the classic antidepressant fluoxetine on intestinal microbiota is still unclear. Aims: To investigate the mechanism of fluoxetine in regulating intestinal microbiota structure and metabolic diversity in rats with depression. Methods: Thirty SD rats were randomly divided into blank group, model group and fluoxetine group. Depression rat model was established by chronic unpredictable mild stress (CUMS) combined with solitary care. Fluoxetine hydrochloride dispersible tablets 3.17 mg•kg
