Interdomain Disulfide Bond Enhances the Stability of Single-chain Antibody Against Pro-gastrin-releasing Peptide

Author: Yu-Feng GUO ¹ ; Ting ZHANG ¹ ; Chao ZHANG ¹ ; Xiao-Na KONG ¹ ; Xiao-Lin ZHOU ¹ ; Jia-Yu LIU ² ; Jing XU ² ; Wei WANG ²
Author Information

1. China Institute of Radiation Protection, Institute of Radiation Medicine and Environmental Medicine
2. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Department of Environmental Medicine, Institute of Biotechnology, Shanxi University
Publication Type:Journal Article
Keywords: disulfide bond; pro-gastrin-releasing peptide (ProGRP); prokaryotic expression; single chain antibody (ScFv); stability
From: Chinese Journal of Biochemistry and Molecular Biology 2022;38(10):1418-1425
CountryChina
Language:Chinese
Abstract: Pro-gastrin-releasing peptide (ProGRP) is a specific marker of small cell lung cancer.