Siglec-15 Promotes the Proliferation and Migration of Colorectal Cancer Cells and Inhibits the Infiltration of CD4
10.13865/j.cnki.cjbmb.2022.03.1632
- Author:
Min-Rong CHENG
1
;
Shu-Hua GAO
1
;
Jin-Xiu ZHENG
1
;
Tao YANG
1
;
Hang-Feng LIU
2
;
Jin-Xiu ZHENG
3
;
Tao YANG
3
Author Information
1. Department of Biochemistry and Molecular Biology, Shanxi Medical University
2. Department of Pharmacology, Shanxi Medical University
3. Key Laboratory of Cell Physiology, Shanxi Medical University, Ministry of Education
- Publication Type:Journal Article
- Keywords:
CD4;
CD8;
colorectal cancer (CRC);
sialic acid-binding immunoglobulin-type lectin-15 (Siglec-15)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2022;38(5):621-629
- CountryChina
- Language:Chinese
-
Abstract:
Sialic acid binding immunoglobulin type lectin-15 (Siglec-15), one of the Siglec gene family members, is a new immunosuppressive molecule. Siglec-15 is highly expressed in a variety of human tumor cells and tumor-associated macrophages, but the biological function of Siglec-15 in colorectal cancer (CRC) and its effect on the tumor immune microenvironment remains poorly understood. This study aimed to investigate the effects of aberrant expression of Siglec-15 on the biological behaviors of CRC cells and the infiltration of CD4
