The Effect of EOGT-Mediated O-Glcnac Modification on Notch Signaling Pathway and Its Role in Diseases
10.13865/j.cnki.cjbmb.2023.02.1416
- Author:
Yuan-Peng MAO
1
;
Hong-Shan WEI
1
Author Information
1. Department of Gastroenterology, Peking University Ditan Teaching Hospital
- Publication Type:Journal Article
- Keywords:
disease;
EGF domain-specific O-linked-N-acetylglucosamine transferase (EOGT);
glycosylation modification;
Notch signaling pathway;
O-linked-N-acetylglucosamine (O-GlcNAc)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2023;39(9):1284-1290
- CountryChina
- Language:Chinese
-
Abstract:
O-linked-N-acetylglucosamine (O-GlcNAc) modification is a unique post-translational modification that plays a regulatory role in many cellular processes, such as transcription, intracellular signaling, endocytosis, and protein stability. Epidermal growth factor (EGF) domain-specific O-GlcNAc transferase (EOGT) is an endoplasmic reticulum (ER) resident protein which can glycosylate the residues of Ser or Thr of secreted or membrane (transmembrane) glycoproteins containing EGF domain. Notch signaling pathway is involved in cell-to-cell communication which regulates cell biological processes through interactions between adjacent cells. To date, EOGT-mediated O-GlcNAc modification has been found to be involved in many human diseases, and shown significant relation with Notch signaling pathway. However, the specific molecular mechanisms have not been fully elucidated. In this review, we briefly introduce recent studies regarding to the roles of EOGT-mediated O-GlcNAc modification and its correlation with Notch signaling pathway in human diseases.
