Suppressing and activating effects of Nogo-B receptors in the pathogenesis of malignant solid tumors
10.16098/j.issn.0529-1356.2021.03.025
- Author:
Hao SU
1
;
Jie REN
1
;
Li-Hua QIN
2
Author Information
1. Clinic Class 4, Peking University Health Science Center
2. Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Peking University Health Science Center
- Publication Type:Journal Article
- Keywords:
Nogo-B;
Receptor;
Signaling pathway;
Tumor
- From:
Acta Anatomica Sinica
2021;52(3):489-494
- CountryChina
- Language:Chinese
-
Abstract:
Nogo-B is a major family member of the reticulon protein family 4. It is widely expressed in the central nervous system and peripheral tissues. Studies have shown that Nogo-B binds to three different receptors; Nogo receptor-1 (NgRl), Nogo-B specific receptor (NgBR) and paired immunoglobulin like receptor B(PirB). These receptors play a dual role of suppression and promotion in angiogenesis, proliferation and apoptosis, invasion and migration, which are important events in tumor development and progression, through various post-receptor signaling pathways, including RhoA/Rho- associated coiled-coil contaning protein kinase (RhoA/ROCK), phosphatidylinositol 3-kinase/protein kinase B (PI3K/ Akt), adenosine 5-monophosphate-activated protein kinase α/liver X receptor α(AMPAa/LXRα), extracellular signal- regulated kinase (ERK), epithelial-mesenchymal transition (EMT), unfolded protein response (UPR) and so on. An in- depth understanding of the mechanisms by which Nogo-B receptors are involved in tumor pathogenesis will provide new insights into the development of drugs. Here, we will summarize the up-to-date researches on the basic structure and expression of Nogo-B/Nogo-B receptors and the suppressing/activating effects of post-receptor signaling pathways in the pathogenesis of malignant solid tumors.
