Relationship of pathogenesis between ischemic stroke and vascular dementia
10.16098/j.issn.0529-1356.2021.05.025
- Author:
Qian-Yu SHI
1
;
Quan-Cheng CHENG
2
;
Chun-Hua CHEN
2
Author Information
1. School of Clinical Medicine, Peking University Health Science Center
2. Department of Human Anatomy and Histo-embryology, School of Basic Medical Sciences, Peking University Health Science Center
- Publication Type:Journal Article
- Keywords:
Blood brain barrier;
Ischemic stroke;
Pathogenesis;
Vascular dementia
- From:
Acta Anatomica Sinica
2021;52(5):834-838
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke could cause brain damage and subsequent cognitive or behavioral disorders. Studies have shown that ischemic stroke is a risk factor of vascular dementia, involving common pathophysiological processes and similar risk factors, which are related in pathogenesis, including endothelial dysfunction and the disrupted blood-brain barrier permeability. Micro infarct, microvascular changes, brain atrophy and neurodegenerative changes may be the pathological mechanism of secondary vascular dementia. However, the specific mechanism of the two is still not fully clarified, which will become the focus of future research.
