Improvement of astaxanthin on learning and memory ability of vascular dementia mice
10.16098/j.issn.0529-1356.2022.01.001
- Author:
Ming ZHANG
1
;
Wei-Cheng MA
1
;
Wei-Juan CAO
2
;
Jia-Ling ZOU
2
;
Ning-Wei ZHU
2
Author Information
1. Pharmaceutical Department, Ningbo Yinzhou Second Hospital
2. Department of Pharmacy, Zhejiang Pharmaceutical College
- Publication Type:Journal Article
- Keywords:
Amyloid beta-peptides 42;
Astaxanthin;
Immunohistochemistry;
Morris water maze;
Mouse;
Vascular dementia;
Western blotting
- From:
Acta Anatomica Sinica
2022;53(1):5-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect and mechanism of astaxanthin on learning and memory ability of vascular dementia (VaD) mice. Methods The mice were used to establish VaD model by occlusion of bilateral common carotid artery. The mice were randomly divided into sham group, model group, astaxanthin low-dose group and astaxanthin high-dose group and then given corresponding forms of drug treatments. Morris water maze was used to investigate the learning, memory and space exploration abilities of mice in each group. At the same time, the pathological morphology of brain neurons, the expression of amyloid beta-peptides 42(Aβ
