Role of ataxia-telangiectasia mutated gene in maintaining quiescence of neural stem cell from subgranular zone of mouse hippocampus
10.16098/j.issn.0529-1356.2022.05.001
- Author:
Chuan-Ming DONG
1
;
Wen-Hua HE
1
Author Information
1. Department of Human Anatomy, Medical College of Nantong University, Jiangsu Key Laboratory of Nerve Regeneration, Collaborative Innovation Center of Nerve Regeneration
- Publication Type:Journal Article
- Keywords:
Ataxia-telangiectasia mutated gene;
Immunofluorescence;
Mouse;
Neural stem cell;
Quiescence
- From:
Acta Anatomica Sinica
2022;53(5):545-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of ataxia-telangiectasia mutated gene (ATM) in maintaining quiescence of neural stem cells (NSCs) from subgranular zone (SGZ) of hippocampal dentate gyms in mice. Methods We constructed 1-month-old and 4-month-old mice ATM knockout mice, with 12 mice in each group. The NSCs in SGZ of ATM knockout mice were isolated, cultured and identified in vitro. The proliferation ability of NSCs in SGZ of 1-month-old ATM
