Effect of chronic restraint stress on the phenotypic transition of hippocampal astrocytes and depression-like behavior in mice
10.16098/j.issn.0529-1356.2023.01.006
- Author:
Meng-Meng SHI
1
;
Jing LI
1
;
Xiang-Lin LUO
1
;
Yuan ZHANG
1
;
Wen-Yu CAO
1
;
Yuan ZHANG
2
;
Yang XU
3
;
Xiao-Lin ZHONG
4
Author Information
1. Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China
2. Hu'nan Provincial Key Laboratory of Tumor Cell and Molecular Pathology, Cancer Institute Medical College, University of South China
3. Department of Physiology, Institute of Neuroscience Medical School, University of SouthChina Hu'nan
4. Institute of Clinical Medicine, The First Affiliated Hospital of University of South China
- Publication Type:Journal Article
- From:
Acta Anatomica Sinica
2023;54(1):42-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of chronic restraint stress (CRS) on the phenotypic transition of hippocampal astrocytes and depression-like behavior in mice. Methods Forty eight male C57BL/6 mice were randomly divided into control groups (control), model groups (CRS) and fluoxetine(FLX) drug intervention groups (CRS+FLX), 16 for each group. The mice of the CRS group were subjected to 3 weeks chronic restraint stress. The mice of CRS + FLX group were treated with fluoxetine by intraperitoneal injection 30 minutes before restraint stress from the day 8 to day 21.
