Relationship between Fok polymorphism of vitamin-D receptor gene and hypertensive disorder complicating pregnancy in Han nationality of Qinghai province
10.16098/j.issn.0529-1356.2023.03.009
- Author:
Zhen WU
1
;
Qian DUAN
1
;
Ming YUAN
1
;
Xue-Ni WANG
1
;
Wen-Jing CHEN
1
;
Jian-Hua LI
1
;
Zhen WU
2
;
Yu-Qin LI
3
;
Yu-Qin E-LUO-JI
3
Author Information
1. Department of Human Anatomy, Basic Medicine Science, Medical College of Qinghai University
2. Department of Ultrasound Medicine, the First Affiliated Hospital of Henan University
3. Department of Obstetrics, Qinghai Provincial People’s Hospital
- Publication Type:Journal Article
- Keywords:
Fok site;
Genetic polymorphism;
Hypertensive disorder complicating pregnancy;
Polymerase chain reaction-restriction fragment length polymorphism;
Pregnant woman;
Qinghai province;
Vitamin-D receptor
- From:
Acta Anatomica Sinica
2023;54(3):313-318
- CountryChina
- Language:Chinese
-
Abstract:
[ Abstract] Objective To investigate the relationship between single nucleotide polymorphism (SNP) Fok (rs2228570 / rs10735810) of vitamin D receptor (VDR) gene and hypertensive disorder complicating pregnancy (HDCP) in Han nationality women of Qinghai province. Methods A total of 137 Han nationality HDCP subjects (HDCP group) and 146 Han nationality normal pregnant subjects (control group) were selected from Qinghai province. The Fok polymorphism typing in HCDP group and control group was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) . The mutation was confirmed by sequencing. SPSS 19. 0 statistical software was used to test whether there were significant differences between two groups in general clinical data, genotype and allele frequency distribution. Results The frequency of FF Ff ff genotype of Fok in HDCP group and control group were 51. 82%, 37. 96%, 10. 22% and 34. 93%, 43. 15%, 21. 92% respectively (
