Research progress in the reprogramming of retinal Müller glia cells
10.16098/j.issn.0529-1356.2023.04.016
- Author:
Xiao-Li ZHANG
1
;
Shu-Qiang ZHANG
1
;
Hui XU
1
Author Information
1. Key Laboratory of Neuroregeneration of Jiangsu, Ministry of Education, Nantong University
- Publication Type:Journal Article
- Keywords:
Müller glia;
Regeneration;
Reprogramming;
Retina;
Zebrafish
- From:
Acta Anatomica Sinica
2023;54(4):484-489
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Blinding eye diseases caused by retinal degeneration have a detrimental effect on human health. Mammalian retina exhibits very limited capacity for self-repair after degenerative disease or injury. In contrast, zebrafish retina possesses a robust regenerative response that regenerates all types of retinal neurons and restores vision. Retina regeneration in zebrafish depends on a type of glia cells called Müller glia. Following retinal injury, zebrafish Müller glia undergo a reprogramming process and proliferate into multipotent progenitor cells that further differentiate into newborn retinal neurons. In recent years, significant progress has been made in the field of Müller glia-based retina regeneration. Here we summarize the mechanisms governing zebrafish retina regeneration and the recent advances in mammalian Müller glia reprogramming.
