Expression and prognostic significance of targeting protein for xenopus kinesin-like protein 2 in hepatocellular carcinoma
10.16098/j.issn.0529-1356.2023.04.009
- Author:
Shao-Guang AN
1
;
Jun-Jie MA
1
;
Hao-Xuan ZANG
2
;
Jin LU
2
;
Hao-Xuan ZANG
3
;
Jin LU
3
Author Information
1. Grade 2020 of Clinical Medical College
2. Anhui Key Laboratory of Computational Medicine and Intelligent Health
3. Department of Human Anatomy, Bengbu Medical College
- Publication Type:Journal Article
- Keywords:
Bioinformatics;
Database analysis;
Disease-free survival;
Hepatocellular carcinoma;
Targeting protein for xenopus kinesin-like protein 2
- From:
Acta Anatomica Sinica
2023;54(4):434-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of targeting protein for xenopus kinesin-like protein 2(TPX2) in hepatocellular carcinoma (HCC) and its clinical prognostic significance. Methods First, the expression levels, survival prognosis and correlation of TPX2 in HCC were analyzed using UALCAN, K-PLOT and HPA databases. Secondly, the TIMER, GEPIA, and SangerBox databases were used to analyze the immune cell infiltration of TPX2, its correlation with TP53 mutation, and the mutation landscape map. Finally, the co-expressed genes of TPX2 in HCC and their prognostic value were analyzed by HCCDB database, and the co-expressed genes were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) were analyzed by the HCCDB database. Results TPX2 was highly expressed in HCC and was not conducive to overall survival(OS), disease-specific survival(DSS), progression-free survival(PFS), and recurrence free survival(RFS) of HCC patients; and its presence in HCC was significantly correlated with tumor cell purity and multiple immune cells (B cells, CD4
