Role and research progress of circular RNA in Alzheimer’s disease

Author: Hong-Fang WANG ¹ ; Dan-Dan GENG ¹ ; Run-Jiao ZHANG ¹ ; Qing LIU ¹ ; Yi-Bo LI ¹ ; Lei WANG ¹ ; Dan-Dan GENG ² ; Lei WANG ²
Author Information

1. Department of Human Anatomy, Institute of Medicine and Health, Hebei Medical University
2. the Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University
Publication Type:Journal Article
Keywords: Alzheimer’s disease; Circular RNA; Neurodegenerative disease
From: Acta Anatomica Sinica 2023;54(4):490-494
CountryChina
Language:Chinese
Abstract: [Abstract] The circular RNA (circRNA) is a class of endogenous expressed non-coding RNA that are formed by covalently closed cyclization through reverse splicing. In recent years, a variety of highly conserved and cell-type specific circRNA have been identified in eukaryotes. Alzheimer’ s disease (AD) is a common neurodegenerative disease and the most common cause of dementia in the elderly. Recent studies had shown that circRNA was involved in the pathogenesis and development of AD, such as amyloid β-protein (Aβ) metabolic, neuroinflammation, oxidative stress, autophagy and synaptic plasticity. The role and application value of circRNA in AD pathology are reviewed to provide a theoretical basis for the application of circRNA in the treatment and diagnosis of AD.