Nuclear factor-KB signaling pathway and gender differences in alcoholic liver fibrosis
10.16098/j.issn.0529-1356.2024.01.008
- Author:
Xiao-Rain HONG
1
;
San-Qiang LI
1
;
Qin-Yi CUI
1
;
Run-Yue ZHENG
1
;
Meng-Li YANG
1
;
Ren-Li LUO
1
;
Qian-Hui LI
2
;
San-Qiang LI
3
Author Information
1. Molecular Medicine Key Laboratory of Liver Injury and Repair, School of Basic Medicine and Forensic Medicine, He'nan University of Science and Technology
2. Department of Anesthesiology, First Affiliated Hospital of Henan University of Science and Technologyo
3. He'nan Province Liver Disease Prevention Engineering Technology Research Cnter
- Publication Type:Journal Article
- Keywords:
Alcoholic liver fibrosis;
Gender differences;
Mouse;
Nuclear factor-KB signaling pathway;
Western blotting
- From:
Acta Anatomica Sinica
2024;55(1):55-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between nuclear factor(NF)-κB signaling pathway and gender differences in alcoholic liver fibrosis. Methods C57BL/6 N mice at 7-8 weeks of age were randomly divided into: male normal group, male model group, female normal group and female model group of 20 mice each. The normal group was fed with control liquid diet for 8 weeks, and the model group was fed with alcoholic liquid diet for 8 weeks combined with 31.5% ethanol gavage (5g/kg twice a week) to establish an alcoholic liver fibrosis model. The mice were executed at the end of 8 weekends, and the alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity, estradiol (E
