Research progress of ketamine psychomimetic symptoms and reward mechanism
10.12092/j.issn.1009-2501.2022.12.004
- Author:
Hang YANG
1
;
Chun YANG
1
;
Wei ZHU
1
;
Fangzhou LU
2
Author Information
1. First Clinical College of Medicine, Nanjing Medical University
2. Department of Anesthesia and Perioperative Medicine, First Affiliated Hospital of Nanjing Medical University
- Publication Type:Journal Article
- Keywords:
drug dependence;
ketamine;
neural mechanism;
psychomimetic symptoms;
reward
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(12):1347-1353
- CountryChina
- Language:Chinese
-
Abstract:
Ketamine is a non-selective N-methyl-D-aspartic acid (NMDA) receptor antagonist. Ketamine plays a significant role in the treatment and research of neuropsychiatric diseases in recent years. The neural mechanism of ketamine psychogenic effects and reward pathway remains to be perfected, which may be closely related to a variety of neurons and pathways in the brain. This paper intends to review the relevant studies at home and abroad, and try to integrate the known neural mechanisms and put forward reasonable hypotheses.
